How To Use Revolution For Cats

Topical Parasiticide For Dogs and Cats

CAUTION

US Federal police force restricts this drug to utilise by or on the guild of a licensed veterinary.

DESCRIPTION

Revolution (selamectin) Topical Parasiticide is available equally a colorless to yellow, set to use solution in single dose tubes for topical (dermal) handling of dogs six weeks of age and older and cats eight weeks of historic period and older. The content of each tube is formulated to provide a minimum of 2.seven mg/lb (six mg/kg) of body weight of selamectin. The chemical composition of selamectin is (5Z,25S)-25-cyclohexyl-4'-O-de(2,6-dideoxy-3-O-methyl-α-50-arabino-hexopyranosyl)-5-demethoxy-25-de(1-methylpropyl)-22,23-dihydro-5-hydroxyiminoavermectin A1a.

INDICATIONS

Revolution is recommended for apply in dogs six weeks of age or older and cats eight weeks of historic period and older for the following parasites and indications:

Dogs:

Revolution kills adult fleas and prevents flea eggs from hatching for one calendar month and is indicated for the prevention and command of flea infestations (Ctenocephalides felis), prevention of heartworm affliction caused past Dirofilaria immitis, and the handling and control of ear mite (Otodectes cynotis) infestations. Revolution likewise is indicated for the treatment and control of sarcoptic mange (Sarcoptes scabiei) and for the control of tick infestations due to Dermacentor variabilis.

Cats:

Revolution kills adult fleas and prevents flea eggs from hatching for one calendar month and is indicated for the prevention and control of flea infestations (Ctenocephalides felis), prevention of heartworm disease acquired by Dirofilaria immitis, and the handling and command of ear mite (Otodectes cynotis) infestations. Revolution is also indicated for the treatment and control of roundworm (Toxocara cati) and abdominal hookworm (Ancylostoma tubaeforme) infections in cats.

WARNINGS

Not for human use. Keep out of the accomplish of children.

In humans, Revolution may exist irritating to skin and eyes. Reactions such equally hives, itching and skin redness accept been reported in humans in rare instances. Individuals with known hypersensitivity to Revolution should use the product with caution or consult a health care professional. Revolution contains isopropyl alcohol and the preservative butylated hydroxytoluene (BHT). Launder hands after use and wash off any product in contact with the skin immediately with soap and water. If contact with eyes occurs, then flush optics copiously with h2o. In instance of ingestion by a human, contact a physician immediately. The safety information sheet (SDS) provides more detailed occupational safety information. For a re-create of the SDS or to report adverse reactions attributable to exposure to this product, call i-888-963-8471.

Combustible - Keep abroad from rut, sparks, open up flames or other sources of ignition.

Do not use in sick, devitalized or underweight animals (see SAFETY).

PRECAUTIONS

Prior to assistants of Revolution, dogs should be tested for existing heartworm infections. At the discretion of the veterinarian, infected dogs should be treated to remove adult heartworms. Revolution is not effective confronting adult D. immitis and, while the number of circulating microfilariae may decrease following treatment, Revolution is not constructive for microfilariae clearance.

Hypersensitivity reactions take non been observed in dogs with patent heartworm infections administered three times the recommended dose of Revolution. College doses were not tested.

ADVERSE REACTIONS

Pre-approval clinical trials:

Following treatment with Revolution, transient localized alopecia with or without inflammation at or nearly the site of awarding was observed in approximately 1% of 691 treated cats. Other signs observed rarely (≤0.v% of 1743 treated cats and dogs) included airsickness, loose stool or diarrhea with or without blood, anorexia, lethargy, salivation, tachypnea, and muscle tremors.

Post-blessing experience:

In addition to the aforementioned clinical signs that were reported in pre-blessing clinical trials, in that location accept been reports of pruritus, urticaria, erythema, ataxia, fever, and rare reports of decease. In that location have besides been rare reports of seizures in dogs (meet WARNINGS).

DOSAGE

The recommended minimum dose is 2.7 mg selamectin per pound (6 mg/kg) of body weight.

Administer the unabridged contents of a single dose tube (or two tubes used in combination for dogs weighing over 130 pounds) of Revolution topically in accordance with the following tables. (See ADMINISTRATION for the recommended treatment intervals.)

Cats (lb)	Packet color	mg per tube	Say-so (mg/mL)	Administered book (mL)
Up to 5	Mauve	xv mg	60	0.25
5.1–15	Blue	45 mg	lx	0.75
xv.1–22	Taupe	60 mg	threescore	i.0

For cats over 22 lbs apply the appropriate combination of tubes.

Dogs (lb)	Package color	mg per tube	Authorization (mg/mL)	Administered volume (mL)
Upwardly to five	Mauve	xv mg	60	0.25
5.1–ten	Royal	30 mg	120	0.25
10.i–20	Brownish	60 mg	120	0.5
20.1–forty	Ruddy	120 mg	120	1.0
40.ane–85	Teal	240 mg	120	2.0
85.1–130	Plum	360 mg	120	3.0

For dogs over 130 lbs use the appropriate combination of tubes.

Recommended for use in dogs half dozen weeks of age and older and in cats viii weeks of age and older.

ADMINISTRATION

A veterinarian or veterinary technician should demonstrate or instruct the pet possessor regarding the appropriate technique for applying Revolution topically to dogs and cats prior to first employ.

Firmly press the cap down to puncture the seal on the Revolution tube; a clicking audio will confirm that the cap has successfully punctured the seal. Remove the cap and check to ensure that the tip of the tube is open. To administrate the product, office the hair on the back of the beast at the base of the neck in front of the shoulder blades until the skin is visible. Place the tip of the tube on the skin and squeeze the tube 3 or iv times to empty its unabridged contents straight onto the skin in i spot. Keeping the tube squeezed, drag information technology away from the liquid and lift to remove. Bank check the tube to ensure that it is empty. Practise not massage the product into the skin. Due to alcohol content, practice non apply to broken pare. Avoid contact between the product and fingers. Practise non apply when the haircoat is wet. Bathing or shampooing the dog 2 or more hours subsequently handling will not reduce the effectiveness of Revolution against fleas or heartworm. Bathing or shampooing the cat 2 hours afterward handling will not reduce the effectiveness of Revolution confronting fleas. Bathing or shampooing the true cat 24 hours after treatment will not reduce the effectiveness of Revolution against heartworm. Stiff hair, clumping of hair, hair discoloration, or a slight powdery residue may be observed at the treatment site in some animals. These effects are temporary and do non touch on the safety or effectiveness of the product. Discard empty tubes in your ordinary household refuse.

Flea Control in Dogs and Cats

For the prevention and command of flea infestations, Revolution should be administered at monthly intervals throughout the flea season, starting ane month before fleas become agile. In controlled laboratory studies >98% of fleas were killed within 36 hours. Results of clinical field studies using Revolution monthly demonstrated >90% control of flea infestations within 30 days of the first dose. Dogs and cats treated with Revolution, including those with pre-existing flea allergy dermatitis, showed improvement in clinical signs associated with fleas every bit a straight result of eliminating the fleas from the animals and their environment.

If the dog or cat is already infested with fleas when the first dose of Revolution is administered, adult fleas on the animal are killed and no viable fleas hatch from eggs after the first administration. All the same, an environmental infestation of fleas may persist for a short time after beginning handling with Revolution because of the emergence of adult fleas from pupae.

Heartworm Prevention in Dogs and Cats

For the prevention of heartworm disease, Revolution must be administered on a monthly basis. Revolution may be administered twelvemonth-circular or at least within one month after the animate being'due south first exposure to mosquitoes and monthly thereafter until the end of the mosquito season. The final dose must be given within one month after the last exposure to mosquitoes. If a dose is missed and a monthly interval betwixt dosing is exceeded then firsthand administration of Revolution and resumption of monthly dosing will minimize the opportunity for the evolution of adult heartworms. When replacing some other heartworm preventive production in a heartworm disease prevention program, the first dose of Revolution must be given inside a month of the last dose of the former medication.

Selamectin, the active ingredient in Revolution, is a macrocyclic lactone chemical compound. These compounds effectively prevent the development of developed heartworms when administered to dogs and cats inside one calendar month of exposure to infective (Fifty3) Dirofilaria immitis larvae. Efficacy of macrocyclic lactones decreases below 100% in dogs, however, if first administered >two months after exposure to infective larvae. Thus, in heartworm owned regions, delaying initiation of heartworm prevention using Revolution across two months of start exposure to infective larvae (e.m., starting puppies and kittens at >eight weeks of age), or gaps of >2 months in the administration of Revolution during periods of heartworm transmission, increases the run a risk of the animal acquiring heartworms. Animals with unknown heartworm history that test negative for heartworms prior to the initiation of Revolution may be harboring pre-patent infections at the time Revolution was started. Testing such animals 3–iv months after initiation of Revolution would be necessary to confirm their negative heartworm condition.

At the discretion of the veterinarian, cats ≥6 months of age may exist tested to make up one's mind the presence of existing heartworm infections earlier beginning treatment with Revolution. Cats already infected with adult heartworms tin be given Revolution monthly to forestall further infections.

Ear Mite Handling in Dogs and Cats

For the treatment of ear mite (O. cynotis) infestations in dogs and cats, Revolution should be administered in one case every bit a unmarried topical dose. A second monthly dose may be required in some dogs. Monthly utilise of Revolution will command any subsequent ear mite infestations. In the clinical field trials ears were non cleaned, and many animals still had debris in their ears after the second dose. Cleansing of the infested ears is recommended to remove the droppings.

Sarcoptic Mange Treatment in Dogs

For the treatment of sarcoptic mange (S. scabiei) in dogs, Revolution should be administered once as a unmarried topical dose. A second monthly dose may be required in some dogs. Monthly use of Revolution will command any subsequent sarcoptic mange mite infestations. Because of the difficulty in finding sarcoptic mange mites on peel scrapings, effectiveness assessments also were based on resolution of clinical signs. Resolution of the pruritus associated with the mite infestations was observed in approximately 50% of the dogs 30 days afterwards the first treatment and in approximately 90% of the dogs thirty days after the 2d monthly treatment.

Tick Control in Dogs

For the command of tick (Dermacentor variabilis) infestations in dogs, Revolution should exist administered on a monthly basis. In heavy tick infestations, complete efficacy may not exist accomplished afterward the kickoff dose. In these cases, one additional dose may be administered 2 weeks after the previous dose, with monthly dosing continued thereafter.

Nematode Treatment in Cats

For the treatment and control of intestinal hookworm (A. tubaeforme) and roundworm (T. cati) infections, Revolution should exist practical once as a unmarried topical dose.

SAFETY

Revolution has been tested safe in over 100 different pure and mixed breeds of healthy dogs and over 15 different pure and mixed breeds of good for you cats, including meaning and lactating females, convenance males and females, puppies six weeks of historic period and older, kittens eight weeks of age and older, and avermectin-sensitive collies. A kitten, estimated to be 5–6 weeks old (0.3 kg), died 8 one⁄2 hours after receiving a single treatment of Revolution at the recommended dosage. The kitten displayed clinical signs which included muscle spasms, salivation and neurological signs. The kitten was a stray with an unknown history and was malnourished and underweight (come across WARNINGS).

DOGS:

In safety studies, Revolution was administered at one, 3, 5, and x times the recommended dose to six-week-old puppies, and no adverse reactions were observed. The safety of Revolution administered orally too was tested in example of accidental oral ingestion. Oral administration of Revolution at the recommended topical dose in 5- to 8-month-onetime beagles did not cause whatsoever agin reactions. In a pre-clinical study selamectin was dosed orally to ivermectin-sensitive collies. Oral administration of 2.5, 10, and 15 mg/kg in this dose escalating study did not cause whatever adverse reactions; yet, eight hours afterward receiving five mg/kg orally, i avermectin-sensitive collie became ataxic for several hours, but did not show whatever other adverse reactions after receiving subsequent doses of 10 and xv mg/kg orally. In a topical rubber study conducted with avermectin-sensitive collies at 1, three and 5 times the recommended dose of Revolution, salivation was observed in all treatment groups, including the vehicle command. Revolution also was administered at 3 times the recommended dose to heartworm infected dogs, and no agin effects were observed.

CATS:

In safety studies, Revolution was applied at 1, iii, 5, and 10 times the recommended dose to six-week-erstwhile kittens. No adverse reactions were observed. The safety of Revolution administered orally also was tested in case of accidental oral ingestion. Oral administration of the recommended topical dose of Revolution to cats caused salivation and intermittent vomiting. Revolution also was applied at 4 times the recommended dose to patent heartworm infected cats, and no adverse reactions were observed.

In well-controlled clinical studies, Revolution was used safely in animals receiving other frequently used veterinary products such equally vaccines, anthelmintics, antiparasitics, antibiotics, steroids, collars, shampoos and dips.

HOW SUPPLIED

Bachelor in eight separate dose strengths for dogs and cats of different weights (come across DOSAGE). Revolution for puppies and kittens is available in cartons containing three single dose tubes. Revolution for cats and dogs is bachelor in cartons containing 3 or six single dose tubes.

Approved past FDA under Zippo # 141-152

zoetis

Manufactured and Distributed by:
Zoetis Inc.
Kalamazoo, MI 49007
Product of the United Kingdom

world wide web.revolutionpet.com

40026639

Client Information

Customer Information About
REVOLUTION® (selamectin)
Revolution (pronounced "Rev-o-lu-tion")
Generic name: selamectin ("sel-a-mec-tin")

This summary contains important information about Revolution. Y'all should read this information earlier you start using Revolution on your dog or true cat and review it each time your prescription is refilled. This sheet is provided only equally a summary and does non take the place of instructions from your veterinarian. Talk to your veterinarian if you practice not understand any of this information or if y'all want to know more than about Revolution.

What is Revolution?

Revolution is a topical parasiticide that is applied to the peel of dogs half dozen weeks of historic period and older and cats eight weeks of age and older to kill adult fleas and forbid flea eggs from hatching, prevent heartworm affliction and protect your pet against other parasites (come across below).

Why has my veterinarian prescribed Revolution?

Revolution has been prescribed past your veterinarian to treat, prevent and/or command the following parasites in your dog or cat:

Dog Parasites:

Control and prevention of flea infestation (Ctenocephalides felis)
Prevention of heartworm affliction (Dirofilaria immitis)
Handling and control of ear mite infestation (Otodectes cynotis)
Handling and control of sarcoptic mange (Sarcoptes scabiei)
Control of the American Dog Tick (Dermacentor variabilis)

True cat Parasites:

Control and prevention of flea infestation (Ctenocephalides felis)
Prevention of heartworm disease (Dirofilaria immitis)
Treatment and command of ear mite infestation (Otodectes cynotis)
Treatment and command of intestinal worms
- Roundworm (Toxocara cati)
- Hookworm (Ancylostoma tubaeforme)

What should I hash out with my veterinary before Revolution is prescribed?

Your veterinarian is all-time suited to discuss and recommend appropriate medications for your dog or cat. It is important to talk over your pet'south health history with your veterinarian so he/she can decide if Revolution is correct for your beast.

Revolution should not exist used in sick, devitalized or underweight animals.

Dogs should exist tested for heartworm disease prior to giving Revolution. If your dog tests positive for adult heartworms, your veterinarian can recommend appropriate treatment. Dogs infected with adult heartworms tin safely be given Revolution.

If your cat is older than six months of historic period, your veterinary may make up one's mind to exam him/her for heartworm disease before prescribing Revolution. Cats infected with adult heartworms tin be given Revolution to prevent further infections.

What dose of Revolution practise I apply on my dog or cat?

Your veterinary will recommend the appropriate dose for your dog or cat based on your creature'southward trunk weight. You should not administer Revolution to dogs younger than 6 weeks of age or cats younger than 8 weeks of historic period. Revolution is available in eight separate dose strengths for dogs and cats of different weights.

What should I practice if I do not requite Revolution on fourth dimension or miss a dose?

If y'all forget to apply a monthly dose of Revolution, immediately apply Revolution, resume monthly applications, and notify your veterinarian.

What if I administrate more than the prescribed corporeality of Revolution to my dog or cat?

Contact your veterinarian if you administer more than than the prescribed amount of Revolution.

How should Revolution be practical?

1. Remove the Revolution tube from its protective package.
ii. Property the tube upright, firmly press the cap downwards until you hear a 'click' sound, which signals that the cap has punctured the applicator seal. Remove the cap and cheque to exist certain that the tip of the tube is open up.
iii. Part the pilus on the back of the animal at the base of operations of the neck, in forepart of the shoulder blades, until the pare is visible.
4. Apply the tip of the Revolution tube direct to the pare. Squeeze the tube firmly 3–4 times in one spot until empty. Keep tube compressed on the final squeeze to avoid cartoon liquid back into tube. Avert contact between Revolution and your fingers.
5. While keeping tube squeezed, drag it away from liquid and lift up to remove.
six. Ensure tube is empty.

Do not massage Revolution into the peel.
Do not apply when the haircoat is wet.
Do not apply to broken skin – Revolution contains alcohol.

Strong hair, clumping of pilus, hair discoloration, or a slight powdery residual may be observed at the site in some animals. These effects are usually temporary and do not touch on the safety or effectiveness of the production.

Tin I give my pet a bath later on applying Revolution?

Yep. Bathing or shampooing the dog ii or more hours after treatment will not reduce the effectiveness of Revolution against fleas or heartworm. Bathing or shampooing the cat 2 hours after treatment will not reduce the effectiveness of Revolution confronting fleas. Bathing or shampooing the cat 24 hours after handling will not reduce the effectiveness of Revolution against heartworm.

When tin I play with my pet following treatment with Revolution?

You should avoid contact with application site when wet. You lot may hold or play with your pet whatever time after the area on which Revolution was practical is dry.

I run into fleas on my dog or cat. Is Revolution working?

Revolution kills adult fleas and prevents flea eggs from hatching. You may occasionally run into a few fleas on dogs or cats treated with Revolution just more than 98% of developed fleas are killed within 36 hours.

Immature stages of the flea called pupae may be present in your pets' surround (grand, flooring, carpet, bedding, etc.). These pupae are non killed by parasiticides (including Revolution) and as such may sally as adult fleas. These adult fleas may hop onto your pet at someday. They must exist exposed to Revolution on your domestic dog or true cat before being killed. It tin take from 3–five weeks (or longer depending on environmental atmospheric condition) for near fleas to complete their 4-stage life cycle (egg, larvae, pupae, and adult) and reach the adult phase earlier beingness seen on your pet. Due to the presence of immature flea stages in infested environments it can take up to 2 to 3 monthly applications for Revolution to maximally control the infestation of fleas in the environment. Once the flea population is controlled you will be less likely to encounter fleas.

I see ticks on my domestic dog. Is Revolution working?

Revolution controls tick infestations only due to the American Dog Tick (Dermacentor variabilis), a tick commonly found on dogs. There are other mutual species of ticks that are not killed or controlled by Revolution. Your veterinary can recommend appropriate products to control or kill ticks common to your area. For the control of the American Domestic dog Tick, Revolution should be applied once a month; however, your veterinarian may recommend a 2d administration applied 14 days after the showtime dose if your dog has a heavy tick infestation and/or recommend additional tick control methods. It may take up to 5 days to kill the majority of ticks on your dog.

What are the possible side effects of Revolution?

Like all medicines, Revolution has some side effects. The most common is pilus loss at the site of application with or without inflammation (redness, flaking) in cats. Other side effects reported in cats and dogs include vomiting, diarrhea with or without claret, anorexia (decreased appetite), lethargy (languor), salivation, rapid animate, pruritus (itching), urticaria (welts, hives), erythema (skin redness), ataxia (incoordination), fever and rare instances of death. In that location have also been rare reports of seizures in dogs.

If you have additional questions about possible side effects, talk to your veterinarian.

Can Revolution be given with other medicines?

In well-controlled clinical studies, Revolution was used safely in dogs and cats receiving other veterinary products such every bit vaccines, anthelmintics, antiparasitics, antibiotics, steroids, collars, shampoos and dips.

Tell your veterinarian about all medicines you have given your dog or cat in the by, and any medicines that you lot are planning to use with Revolution. This should include other medicines that yous can get without a prescription. Your veterinarian may want to check that all of your canis familiaris's or cat's medicines can be given together.

How should Revolution be stored?

Revolution is combustible – Keep away from oestrus, sparks, open up flames or other sources of ignition. Store beneath 30°C (86°F). Afterward application, empty tubes can be placed in your normal household refuse for disposal.

What else should I know about Revolution?

Revolution is not for use in humans. Revolution should exist kept out of attain of children. In humans, Revolution may be irritating to skin and eyes. Reactions such as hives, itching and skin redness have been reported in humans in rare instances. Individuals with known hypersensitivity to Revolution should use the product with circumspection or consult a wellness intendance professional. Revolution contains isopropyl alcohol and the preservative butylated hydroxytoluene (BHT). Wash easily after use and wash off any product in contact with the peel immediately with soap and water. In case of human ingestion contact a physician immediately.

Revised: March 2019

zoetis

Manufactured and Distributed by:
Zoetis Inc.
Kalamazoo, MI 49007
Product of the United Kingdom

40026639